{"id":42179,"date":"2025-11-21T16:59:07","date_gmt":"2025-11-21T11:29:07","guid":{"rendered":"https:\/\/edunovations.com\/currentaffairs\/?p=42179"},"modified":"2025-11-21T16:59:09","modified_gmt":"2025-11-21T11:29:09","slug":"nitric-oxide-wound-dressing-india","status":"publish","type":"post","link":"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/","title":{"rendered":"Nitric Oxide Wound Dressing India: DAE Launches ColoNoX for Diabetic Foot Ulcers"},"content":{"rendered":"\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Nitric_oxide_wound_dressing_India_DAE_launches_ColoNoX_Indias_first_NO-based_collagen_dressing_for_diabetic_foot_ulcers_boosting_wound_healing_and_public_health\" >Nitric oxide wound dressing India: DAE launches ColoNoX, India\u2019s first NO-based collagen dressing for diabetic foot ulcers, boosting wound healing and public health.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Revolution_in_Wound_Care_DAE_Unveils_Nitric%E2%80%91Oxide_Dressing_for_Diabetic_Foot_Ulcers\" >Revolution in Wound Care: DAE Unveils Nitric\u2011Oxide Dressing for Diabetic Foot Ulcers<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Introduction\" >Introduction<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#What_Is_ColoNoX_How_It_Works\" >What Is ColoNoX &amp; How It Works<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Regulatory_Clinical_Validation\" >Regulatory &amp; Clinical Validation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Significance_for_Public_Health\" >Significance for Public Health<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Strategic_Mineral_Science_Innovation\" >Strategic Mineral Science Innovation<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Why_This_News_Is_Important\" >Why This News Is Important<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Significance_for_Healthcare\" >Significance for Healthcare<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Innovation_from_Nuclear_Science\" >Innovation from Nuclear Science<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Strategic_Mineral_Capability\" >Strategic Mineral Capability<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Policy_Self-Reliance\" >Policy &amp; Self-Reliance<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Historical_Context\" >Historical Context<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#BARC_NO%E2%80%91Releasing_Technology\" >BARC &amp; NO\u2011Releasing Technology<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Clinical_Validation_Collaboration\" >Clinical Validation &amp; Collaboration<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Regulatory_Pathway\" >Regulatory Pathway<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Strategic_Minerals_and_CRM\" >Strategic Minerals and CRM<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Key_Takeaways_from_This_News\" >Key Takeaways from This News<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#FAQs_Frequently_Asked_Questions\" >FAQs: Frequently Asked Questions<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#1_What_is_ColoNoX\" >1. What is ColoNoX?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#2_Who_developed_ColoNoX\" >2. Who developed ColoNoX?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#3_How_does_nitric_oxide_help_in_wound_healing\" >3. How does nitric oxide help in wound healing?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#4_Is_ColoNoX_approved_for_clinical_use\" >4. Is ColoNoX approved for clinical use?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#5_How_long_can_ColoNoX_be_stored\" >5. How long can ColoNoX be stored?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#6_What_is_BARC_B140_CRM\" >6. What is BARC B140 CRM?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#7_Why_is_this_innovation_important_for_India\" >7. Why is this innovation important for India?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/edunovations.com\/currentaffairs\/national\/nitric-oxide-wound-dressing-india\/#Some_Important_Current_Affairs_Links\" >Some Important Current Affairs Links<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nitric_oxide_wound_dressing_India_DAE_launches_ColoNoX_Indias_first_NO-based_collagen_dressing_for_diabetic_foot_ulcers_boosting_wound_healing_and_public_health\"><\/span>Nitric oxide wound dressing India: DAE launches ColoNoX, India\u2019s first NO-based collagen dressing for diabetic foot ulcers, boosting wound healing and public health.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Revolution_in_Wound_Care_DAE_Unveils_Nitric%E2%80%91Oxide_Dressing_for_Diabetic_Foot_Ulcers\"><\/span>Revolution in Wound Care: DAE Unveils Nitric\u2011Oxide Dressing for Diabetic Foot Ulcers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Introduction\"><\/span>Introduction<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The <strong>Department of Atomic Energy (DAE)<\/strong> has made a breakthrough by launching <strong>ColoNoX<\/strong>, India\u2019s first nitric-oxide (NO)\u2013releasing wound dressing. Developed by the <strong>Bhabha Atomic Research Centre (BARC)<\/strong> in collaboration with <strong>Cologenesis Pvt. Ltd.<\/strong>, this innovative dressing is designed specifically to treat <strong>diabetic foot ulcers (DFU)<\/strong> \u2014 a serious complication of diabetes that can lead to amputations. Alongside this, DAE also introduced a <strong>Certified Reference Material (CRM)<\/strong> for rare-earth element (REE) research, marking a dual achievement in health and strategic mineral sciences. <\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Is_ColoNoX_How_It_Works\"><\/span>What Is ColoNoX &amp; How It Works<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Design and Development<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ColoNoX was developed through a technology transfer from BARC to Cologenesis under BARC\u2019s Technology Transfer Program.<\/li>\n\n\n\n<li>The dressing is built on a <strong>collagen hydrogel matrix<\/strong>, which helps absorb wound exudate (fluid) and offers a scaffold for tissue regeneration.<\/li>\n<\/ul>\n\n\n\n<p><strong>Mechanism of Action<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The key active component is <strong>nitric oxide (NO or NOx)<\/strong>, a gaseous signaling molecule. <\/li>\n\n\n\n<li>NO is released in a controlled manner at the wound site, which supports multiple healing processes:\n<ul class=\"wp-block-list\">\n<li><strong>Antimicrobial activity<\/strong>: NO penetrates biofilms and kills bacteria\/fungi, reducing infection. <\/li>\n\n\n\n<li><strong>Angiogenesis &amp; Granulation<\/strong>: It stimulates the formation of new blood vessels (microvascularization) and promotes the growth of granulation tissue \u2014 essential for healing. <\/li>\n\n\n\n<li><strong>Collagen deposition<\/strong>: The collagen scaffold attracts fibroblasts, keratinocytes, and other cells, helping tissue rebuild.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>Stability &amp; Cost-Effectiveness<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The dressing is stable: it can be stored for <strong>up to two years at room temperature and humidity<\/strong> without losing its activity.<\/li>\n\n\n\n<li>It is <strong>relatively inexpensive to produce<\/strong>, making it accessible for widespread adoption. <\/li>\n\n\n\n<li>Because of the NO-based mechanism, there is <strong>less risk of microbial resistance<\/strong>, an important advantage over traditional antibiotic dressings<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Regulatory_Clinical_Validation\"><\/span>Regulatory &amp; Clinical Validation<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ColoNoX has successfully undergone <strong>Phase II and Phase III clinical trials<\/strong>, demonstrating its safety and efficacy for DFU treatment.<\/li>\n\n\n\n<li>It has received approval from the <strong>Drugs Controller General of India (DCGI)<\/strong> for commercial manufacturing. <\/li>\n\n\n\n<li>This regulatory milestone means the product can now be manufactured and made available to the healthcare system. <\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Significance_for_Public_Health\"><\/span>Significance for Public Health<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Diabetic foot ulcers are a <strong>major health burden<\/strong> in India, given the high prevalence of diabetes. <\/li>\n\n\n\n<li>By combining <strong>antimicrobial action, blood-flow improvement, and tissue regeneration<\/strong>, ColoNoX can potentially <strong>reduce healing time<\/strong>, lower risk of infections, and <strong>minimise amputation risk<\/strong>.<\/li>\n\n\n\n<li>Moreover, by being <strong>affordable and effective<\/strong>, it aligns with DAE\u2019s mission to translate nuclear science into societal benefits. DAE Secretary Dr. Ajit\u202fKumar Mohanty emphasized this point, calling it a \u201cmeaningful step\u201d in serving national health. <\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Strategic_Mineral_Science_Innovation\"><\/span>Strategic Mineral Science Innovation<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aside from ColoNoX, the DAE also launched <strong>Ferrocarbonatite (FC) \u2013 BARC B140<\/strong>, India\u2019s first <strong>Certified Reference Material (CRM)<\/strong> for rare-earth elements. <\/li>\n\n\n\n<li>Developed by BARC\u2019s <strong>National Centre for Compositional Characterisation of Materials (NCCCM)<\/strong> and the <strong>Atomic Minerals Directorate (AMD)<\/strong>, Hyderabad, this CRM provides <strong>certified values for 13 REEs and 6 other major elements<\/strong>. <\/li>\n\n\n\n<li>This is only the <strong>fourth CRM of its kind globally<\/strong>, and the first to be developed in India. <\/li>\n\n\n\n<li>The CRM will help <strong>improve accuracy in rare-earth mineral exploration, extraction, and process control<\/strong>, reinforcing India\u2019s capabilities in strategic mineral research. <\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\" id=\"Nitric-oxide-wound-dressing-India\"><img decoding=\"async\" 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\" alt=\"Nitric oxide wound dressing India\" title=\"Nitric oxide wound dressing India\"\/><figcaption class=\"wp-element-caption\">Nitric oxide wound dressing India<\/figcaption><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Why_This_News_Is_Important\"><\/span>Why This News Is Important<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Significance_for_Healthcare\"><\/span>Significance for Healthcare<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>This development is a major win for public health \u2014 diabetic foot ulcers (DFUs) are notoriously difficult to treat and often lead to severe complications, including amputations. An affordable and effective NO\u2011releasing dressing like ColoNoX can <strong>transform wound care for diabetic patients<\/strong>, especially in resource-limited settings.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Innovation_from_Nuclear_Science\"><\/span>Innovation from Nuclear Science<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>It underscores how <strong>nuclear science isn\u2019t just about energy or weapons<\/strong>; institutions like BARC are applying their deep scientific expertise to create medically relevant technologies. This aligns with governmental goals of \u201cAtoms in the service of the nation.\u201d <\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Strategic_Mineral_Capability\"><\/span>Strategic Mineral Capability<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>On the mineral science front, the certified reference material (CRM) for rare-earth elements boosts India\u2019s <strong>mining and processing capabilities<\/strong>. Rare earths are critical for modern technologies \u2014 from electronics to defense systems \u2014 so having an indigenous standard helps strengthen strategic autonomy.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Policy_Self-Reliance\"><\/span>Policy &amp; Self-Reliance<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The launch also supports <strong>Make in India<\/strong> and <strong>Atmanirbhar Bharat<\/strong> agendas. By commercializing home-grown innovations (both in healthcare and mineral sciences), India is reducing reliance on foreign tech and improving its scientific sovereignty. <\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Historical_Context\"><\/span>Historical Context<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"BARC_NO%E2%80%91Releasing_Technology\"><\/span>BARC &amp; NO\u2011Releasing Technology<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The idea of using nitric oxide (NO) in wound healing is not entirely new. BARC had previously developed and patented a NOx (nitrogen oxides) releasing wound dressing for chronic, non-healing wounds (such as diabetic foot ulcers, pressure ulcers, venous stasis wounds). <\/p>\n\n\n\n<p>Nitric oxide is a natural signaling molecule in the body that plays multiple roles \u2014 controlling infection, regulating blood vessel formation, and encouraging tissue repair. BARC\u2019s version also uses a <strong>collagen scaffold<\/strong>, which has been shown to support cell-based tissue repair, making it particularly suitable for skin regeneration.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Clinical_Validation_Collaboration\"><\/span>Clinical Validation &amp; Collaboration<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Over the years, BARC collaborated with <strong>Cologenesis Pvt. Ltd.<\/strong> to translate lab-scale NO-releasing dressing into a clinically usable product. Clinical trials (Phase II &amp; III) validated its efficacy and safety. <br>The <strong>Technology Transfer Program<\/strong> of BARC helped in licensing the technology to Cologenesis for mass manufacture. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Regulatory_Pathway\"><\/span>Regulatory Pathway<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>After successful clinical trials, <strong>DCGI approval<\/strong> was secured, enabling commercial production. <br>This journey\u2014from lab to clinic to market\u2014is a good example of <strong>scientific research being translated into real-world solutions<\/strong>, particularly in a public health context.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Strategic_Minerals_and_CRM\"><\/span>Strategic Minerals and CRM<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>In parallel, BARC\u2019s NCCCM and AMD worked on creating a <strong>Certified Reference Material (CRM)<\/strong> for rare-earth elements. Such CRMs are crucial for ensuring accuracy and consistency in mineral exploration and processing \u2014 especially for rare-earth elements, which are strategic for many modern technologies.<\/p>\n\n\n\n<p>Before this, India did <strong>not have an indigenous CRM<\/strong> for REEs; this new CRM (BARC B140) places India among a select few countries globally that have such certified materials. <\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Key_Takeaways_from_This_News\"><\/span>Key Takeaways from This News<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>#<\/th><th>Key Takeaway<\/th><\/tr><\/thead><tbody><tr><td>1<\/td><td><strong>ColoNoX<\/strong> is India\u2019s first nitric-oxide\u2011releasing wound dressing, developed for diabetic foot ulcers (DFU). <\/td><\/tr><tr><td>2<\/td><td>The dressing combines <strong>nitric oxide<\/strong> and <strong>collagen hydrogel<\/strong> to boost healing, fight infection, and improve blood flow. <\/td><\/tr><tr><td>3<\/td><td>It has been clinically validated (Phase II &amp; III trials) and has <strong>DCGI approval<\/strong> for commercial manufacturing. <\/td><\/tr><tr><td>4<\/td><td>The dressing is <strong>stable at room temperature<\/strong> for up to two years, cost-effective, and less likely to drive microbial resistance. <\/td><\/tr><tr><td>5<\/td><td>DAE also launched <strong>BARC B140 Ferrocarbonatite CRM<\/strong>, India\u2019s first indigenous Certified Reference Material for rare-earth elements, supporting strategic mineral research.<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">Nitric oxide wound dressing India<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs_Frequently_Asked_Questions\"><\/span>FAQs: Frequently Asked Questions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_What_is_ColoNoX\"><\/span>1. What is ColoNoX?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>ColoNoX is India\u2019s first <strong>nitric-oxide (NO) releasing wound dressing<\/strong> designed to treat <strong>diabetic foot ulcers (DFU)<\/strong>. It uses a collagen hydrogel matrix to promote wound healing and prevent infections.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_Who_developed_ColoNoX\"><\/span>2. Who developed ColoNoX?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>It was developed by <strong>Bhabha Atomic Research Centre (BARC)<\/strong> in collaboration with <strong>Cologenesis Pvt. Ltd.<\/strong>, under the Department of Atomic Energy (DAE) technology transfer program.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_How_does_nitric_oxide_help_in_wound_healing\"><\/span>3. How does nitric oxide help in wound healing?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Nitric oxide (NO) acts as a <strong>signaling molecule<\/strong> to fight infections, stimulate <strong>blood vessel formation<\/strong>, and encourage <strong>tissue regeneration<\/strong>, speeding up wound healing.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_Is_ColoNoX_approved_for_clinical_use\"><\/span>4. Is ColoNoX approved for clinical use?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Yes. ColoNoX has successfully passed <strong>Phase II and III clinical trials<\/strong> and received <strong>DCGI approval<\/strong> for commercial manufacturing in India.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_How_long_can_ColoNoX_be_stored\"><\/span>5. How long can ColoNoX be stored?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The dressing is stable for up to <strong>two years at room temperature and humidity<\/strong> without losing its efficacy.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_What_is_BARC_B140_CRM\"><\/span>6. What is BARC B140 CRM?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>BARC B140 is India\u2019s first <strong>Certified Reference Material (CRM)<\/strong> for rare-earth elements (REEs), used to ensure <strong>accuracy in mineral research and processing<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7_Why_is_this_innovation_important_for_India\"><\/span>7. Why is this innovation important for India?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>It supports <strong>public health<\/strong> by providing an affordable, effective solution for DFU, strengthens <strong>strategic mineral research<\/strong>, and aligns with <strong>Atmanirbhar Bharat<\/strong> initiatives.<\/p>\n\n\n\n<p><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Some_Important_Current_Affairs_Links\"><\/span>Some Important Current Affairs Links<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/edunovations.com\/currentaffairs\/category\/national\/\" target=\"_blank\" rel=\"noreferrer noopener\">State Current Affairs<\/a><\/div>\n\n\n\n<div class=\"wp-block-button is-style-outline is-style-outline--2\"><a 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Revolution in Wound Care: DAE Unveils Nitric\u2011Oxide Dressing for Diabetic Foot Ulcers Introduction The Department of Atomic Energy (DAE) has made a breakthrough by launching ColoNoX, India\u2019s first nitric-oxide (NO)\u2013releasing wound dressing&#8230;.<\/p>\n","protected":false},"author":6,"featured_media":42215,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,153],"tags":[30627,30628,30630,30632,29438,30629,30631],"class_list":["post-42179","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-national","category-miscellaneous","tag-barc-innovation","tag-colonox","tag-dae-news","tag-diabetic-foot-ulcer","tag-indian-healthcare-innovation","tag-nitric-oxide-therapy","tag-rare-earth-element-crm"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/posts\/42179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/comments?post=42179"}],"version-history":[{"count":3,"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/posts\/42179\/revisions"}],"predecessor-version":[{"id":42222,"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/posts\/42179\/revisions\/42222"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/media\/42215"}],"wp:attachment":[{"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/media?parent=42179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/categories?post=42179"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/edunovations.com\/currentaffairs\/wp-json\/wp\/v2\/tags?post=42179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}